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What are the commonly used pharmaceutical packaging materials?

What are the commonly used pharmaceutical packaging materials?

Oct 13.2023
① Glass: Glass has advantages such as moisture resistance, easy sealing, transparency, and relatively stable chemical properties, but it also has many disadvantages, such as being heavy, and fragile, and can release alkaline substances and insoluble detachment due to erosion by aqueous solutions. To ensure the quality of drugs, Pharmacopoeia stipulates that ampoules and large infusion bottles must be made of hard neutral glass. When containing drugs that are prone to deterioration when exposed to light, containers made of brown glass should be used.
② Plastic: Plastic has the advantages of strong packaging, easy sealing, bright color, transparent and beautiful appearance, lightweight, convenient carrying, and low price. However, due to the frequent addition of additives such as plasticizers and stabilizers in the production of plastics, these additives may directly come into contact with drugs and may undergo chemical reactions, resulting in changes in drug quality. Plastics also have drawbacks such as breathability, transparency, and easy adsorption, which can accelerate the rate of drug oxidation and deterioration, causing drug deterioration.
③ Paper products: Paper products come from a wide range of sources, have low costs, and have certain moisture-proof properties after being coated with moisture-proof coatings. The packaging volume can be manufactured according to needs, and have the value of recycling. It is one of the widely used packaging materials today. Disadvantages: Low strength and easy deformation.
④ Metal: Commonly used are black iron sheets, galvanized iron sheets, tinplate, aluminum foil, etc. This type of packaging has good pressure resistance, sealing, and performance, but its cost is relatively high.
⑤ Wood: It has pressure resistance and is a commonly used outer packaging material. Due to its consumption of forest resources, it has gradually been replaced by materials such as paper and plastic.
⑥ Composite materials: Composite materials are the emerging trend in packaging materials, which are made of multi-layer composite materials such as plastic, paper, aluminum foil, etc. Commonly used include paper-plastic composite materials, aluminum foil polyethylene composite materials, aluminum foil polyester ethylene, etc. These composite materials have good mechanical strength, biological corrosion resistance, vacuum retention performance, and compressive performance.
⑦ Rubber products: mainly used for various bottle stoppers of bottled drugs. Due to direct contact with drugs, it is required to have very good biochemical stability and sealing to ensure that they do not deteriorate due to the entry of air and moisture within the validity period.
From the perspective of development trends, packaging materials are moving towards replacing wood with paper, plastic with paper, or various composite materials composed of paper, plastic, aluminum foil, etc. The application of special packaging materials, such as polytetrafluoroethylene, organic silicone resin, polyester composite board, or foam polyurethane, is on the rise.